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. 2020 Nov 22;12(11):732. doi: 10.3390/toxins12110732

Figure 6.

Figure 6

Effect of OTA expositions on the Gsta gene expression in the kidney cortex. A: Gsta gene expression alterations of the single oral dose (24 h) OTA-treated kidney samples. The highest OTA dose decreased the Gsta mRNA level (p < 0.01). B: Gsta gene expression alterations of the repeated daily oral dose (72 h) OTA-treated kidney samples. Both applied OTA doses decreased the Gsta mRNA levels (p < 0.01). C: Gsta gene expression alterations of the repeated daily oral dose (21 days) OTA-treated kidney samples. OTA treatment did not influence the Gsta mRNA level. Abbreviations: MMS: methyl-methanesulfonate-treated group; OTA 1 and OTA 10: 1 and 10 mg/kg bw ochratoxin-A-treated groups in the single oral dose (24 h) and repeated daily oral dose (72 h) experiment; OTA 0.5: 0.5 mg/kg bw ochratoxin-A-treated group in the repeated daily oral dose (21 days) experiment. Mean ± S.D. Data were analyzed by one-way ANOVA and Tukey’s post hoc test. * p < 0.05, ** p < 0.01, *** p < 0.001 vs. vehicle.