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. 2020 Nov 22;12(11):732. doi: 10.3390/toxins12110732

Figure 8.

Figure 8

Effect of OTA expositions on the Nrf2 mRNA expression levels in the kidney. (A) Nrf2 gene mRNA expressions of the single oral dose (24 h) OTA-treated kidney samples. Both applied OTA doses increased the Nrf2 mRNA levels (p < 0.01 and 0.0001, respectively). (B) Nrf2 gene expression levels of the repeated daily oral dose (72 h) OTA-treated kidney samples. Both applied OTA doses increased the Nrf2 mRNA levels (p < 0.01 and 0.0001, respectively). (C) Nrf2 gene expression alterations of the repeated daily oral dose (21 days) OTA-treated kidney samples. The applied OTA dose increased the Nrf2 mRNA level (** p < 0.01). Abbreviations: MMS: methyl-methanesulfonate-treated group; OTA 1 and OTA 10: 1 and 10 mg/kg bw ochratoxin-A-treated groups in the single oral dose (24 h) and repeated daily oral dose (72 h) experiment; OTA 0.5: 0.5 mg/kg bw ochratoxin-A-treated group in the repeated daily oral dose (21 days) experiment. Mean ± S.D. Data were analyzed by one-way ANOVA and Tukey’s post hoc test. ** p < 0.01, **** p < 0.0001 vs. vehicle.