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. 2020 Nov 22;12(11):732. doi: 10.3390/toxins12110732

Figure 13.

Figure 13

Effect of OTA expositions on the Nqo1 mRNA expression levels in the kidney. A: Nqo1 gene mRNA expressions of the single oral dose (24 h) OTA-treated kidney samples. Both applied OTA doses decreased the Nqo1 mRNA levels (p < 0.01 and p < 0.001, respectively). B: Nqo1 gene expression levels of the repeated daily oral dose (72 h) OTA-treated kidney samples. Both applied OTA doses decreased the Nqo1 mRNA levels (p < 0.01, and p < 0.05, respectively). C: Nqo1 gene expression alterations of the repeated daily oral dose (21 days) OTA-treated kidney samples. The OTA treatment did not have a significant effect on the Nqo1 mRNA level. Abbreviations: MMS: methyl-methanesulfonate-treated treated group; OTA 1 and OTA 10: 1 and 10 mg/kg bw ochratoxin-A-treated groups in the single oral dose (24 h) and repeated daily oral dose (72 h) experiment; OTA 0.5: 0.5 mg/kg bw ochratoxin-A-treated group in the repeated daily oral dose (21 days) experiment. Mean ± S.D. Data were analyzed by one-way ANOVA and Tukey’s post hoc test.* p < 0.05, ** p < 0.01, *** p < 0.001, **** p < 0.0001 vs. vehicle.