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Crystal structure of the Su(var)3-9, Enhancer-of-zeste and Trithorax domain (SET domain) of Clr4 showing the sequence and approximate position of its autoregulatory loop (ARL), which is disordered in the structure (pdb 6BP4, [40]). The automethylated lysines K455 and K472 are marked in red, the amino acids surrounding K455 at −1, +1 and +2 positions which were mutated are marked in green.
