Figure 6.

SA inhibits oxidative stress in PE-stimulated hypertrophic cardiomyocytes. (A) DCFH-DA dye for ROS production, (B) MDA, and (C) catalase were measured in cardiomyocytes pretreated with 100, 200, and 400 μM SA for 24 h, followed by treatment with 100 μM PE. Data are expressed as the mean ± standard error of the mean (SEM). Significance was assessed by one-way analysis of variance (ANOVA) with a Bonferroni post hoc test. ^## P < 0.01 and ^### P < 0.001 vs. the control group; ^* P < 0.05, ^** P < 0.01, and ^*** P < 0.001 vs. the PE-only treated group. Veh, vehicle-treated; SA100, SA200, and SA400, 100, 200, and 400 μM SA-treated groups, respectively; MDA, malondialdehyde; PE, phenylephrine; Cont, control; SA, sinapic acid.