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. 2020 Nov 21;9(11):3743. doi: 10.3390/jcm9113743

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© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Combined ACE2 network with SARS-CoV-2/Human interactome and co-expression network in infected human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs). (A) Hub nodes identified in the co-expression network analysis of infected hiPSC-CMs using the NERI algorithm, showing the highest connectivity with SARS-CoV-2/Human interactome (top 15 genes). (B) SARS-CoV-2/Human interactome as shown in previously published work [39]. (C) ACE2 network components that interact with SARS-CoV-2/Human interactome proteins. Nodes from network A which have the highest connectivity are sorted from right to left. Nodes from the networks B and C are circularly sorted by the number of connections with virus interactome. Virus proteins are shown as orange octagons, while virus-infection related human proteins have red labels.