Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Nov 21;9(11):3743. doi: 10.3390/jcm9113743

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Top 20 potential miRNA modulators of the ACE2 network in COVID-19. (A) Top miRNAs regulating the highest number of genes within all ACE2 related-networks. Pink squares are showing if miRNA was present among the top 10 miRNAs in a given dataset. (B) Interaction network between virus-infection related proteins (red labels) and top miRNAs (bolded label on the A panel) regulating ACE2 and shared between analyzed networks and regulating at least four virus-related proteins from the complete network. Numbers on the right side of the miRNAs depict the number of targeted genes within the network. CCL2 and FABP2 genes are not direct interactors of the ACE2, so they are presented outside of the ACE2-interactors box. “S” refers to SARS-CoV-2 spike glycoprotein S. Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs).