Skip to main content
. 2020 Nov 21;9(11):3743. doi: 10.3390/jcm9113743
ACE2 Angiotensin-Converting Enzyme 2
ACE Angiotensin-Converting Enzyme 1
ARDS Acute respiratory distress syndrome
COVID-19 Coronavirus disease 2019
CVD Cardiovascular disease
DEG Differentially expressed genes
DM Diabetes mellitus
eNOS Endothelial nitric oxide synthase
GEO Gene Expression Omnibus
GO Gene Ontology
GPCRs G-protein-coupled receptors
GTEx Genotype-Tissue Expression
HF Heart failure
HK High molecular weight kininogen
hiPSC-CMs Human-induced pluripotent stem cell-derived cardiomyocytes
INS Insulin
KKS Kallikrein-Kinin system
KNG1 Kininogen 1
MERS Middle-East respiratory syndrome coronavirus
MI Myocardial infarction
miRNAs, miR MicroRNAs
NERI NEtwork by Relative Importance
NT-proBNP N-terminal pro-B-type natriuretic peptide
PPI Protein–protein interaction
RAS Renin–angiotensin system
REN Renin
ROS Reactive oxygen species
SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2
TMPRSS2 Transmembrane protease serine 2
Gene/protein
ACE2 Angiotensin-Converting Enzyme 2
ADAM17 ADAM metallopeptidase domain 17
AGT Angiotensinogen
AGTR1 Angiotensin II Receptor Type 1
ALB Albumin
APP Amyloid Beta Precursor Protein
ANPEP Alanyl Aminopeptidase
APN/CD13 Aminopeptidase N/CD13
ATP6AP2 ATPase H+ Transporting Accessory Protein 2
CALM1 Calmodulin 1
CAT Catalase
CAV1 Caveolin-1
CCL2 C-C Motif Chemokine Ligand 2
CCN2 Cellular Communication Network Factor 2
CDHR2 Cadherin Related Family Member 2
CDK4 Cyclin-Dependent Kinase 4
CLEC4M C-Type Lectin Domain Family 4 Member M
CTSA Cathepsin A
CTSG Cathepsin G
DPP4 Dipeptidyl Peptidase 4
EGFR Epidermal Growth Factor Receptor
ENPEP Glutamyl Aminopeptidase
EV71 Enterovirus 71
EWSR1 EWS RNA Binding Protein 1 (EWSR1)
FABP2 Fatty acid-binding protein 2
FN1 Fibronectin 1
FoxO2 Forkhead box O-2
HSP90AA1 Heat Shock Protein 90 Alpha Family Class A Member 1
INS Insulin
KNG1 Kininogen 1
KPNA2 Karyopherin Subunit Alpha 2
LNPEP Leucyl And Cystinyl Aminopeptidase
LTA4H Leukotriene A4 hydrolase
MAPK Mitogen-activated protein kinase
MAST2 Microtubule Associated Serine/Threonine Kinase 2
MCP-1 Monocyte chemoattractant protein-1
MEP1A Meprin A subunit alpha
MME Membrane metallo-endopeptidase
MS4A10 Membrane Spanning 4-Domains A10
NFKB1 Nuclear Factor Kappa B Subunit 1
NF-κB Nuclear factor kappa-light-chain-enhancer of activated B cells
NPC1 Niemann-Pick disease, type C1
PAI-1 Plasminogen activator inhibitor-1
PDGFR-b Platelet-derived growth factor receptor-beta
PPARγ Peroxisome proliferator-activated receptor-gamma
PRCP Prolyl-carboxypeptidase
TFRC Transferrin Receptor
TGFB1 Transforming Growth Factor Beta 1
THOP1 Thimet Oligo-peptidase 1
TMPRSS2 Transmembrane protease, serine 2
VEGFR2 Vascular endothelial growth factor receptor 2
Signaling pathways
AGE-RAGE Advanced glycation end products-Receptor for Advanced glycation end products
ERK1/2/AP-1 Extracellular signal-regulated kinases 1/2/AP-1
PI3K/AKT/Nrf2 Phosphatidylinositol 3′-kinase/AKT/NF-E2-related factor 2
ERK1/2/AP-1 Extracellular signal-regulated kinases 1/2/AP-1
PI3K/AKT/Nrf2 Phosphatidylinositol 3′-kinase/AKT/NF-E2-related factor 2
RAS Renin-Angiotensin System