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Estrogen-related gene expression is dependent on dimensionality in 12Z cells. CYP19A1 and HSD17β1, genes involved in estrogen synthesis, are upregulated in 12Z cells grown as spheroids compared to monolayer. ESR1, an estrogen receptor, is also increased in spheroids compared to monolayer. RQ = relative quantification. N ≥ 3. *p < 0.05, ** p < 0.01.
