Table 2.
Yeast complex III subunits and their human homologs. The table also shows Complex III assembly factors that are associated with diseases.
| Yeast Gene | Genome | pet Mutant | Human Gene | Function | |
|---|---|---|---|---|---|
| Enzyme Subunits | COB | mitochondrial | N/A | MT-CYB | catalysis |
| CYT1 | nuclear | yes | CYC1 | catalysis | |
| RIP1 | nuclear | yes | UQCRFS1 | catalysis | |
| COR1 | nuclear | yes | UQCRC1 | structure | |
| COR2 | nuclear | yes | UQCRC2 | structure | |
| QCR6 | nuclear | no | UQCRH | structure | |
| QCR8 | nuclear | yes | UQCRQ | structure | |
| QCR7 | nuclear | yes | UQCRB | structure | |
| QCR9 | nuclear | no | UQCR10 | structure | |
| QCR10 | nuclear | no | UQCR11 | structure | |
| Assembly Factors | CBP3 | nuclear | yes | UQCC1 | translation/assembly of cyt. b |
| CBP6 | nuclear | yes | UQCC2 | translation/assembly of cyt. b | |
| CBP4 | nuclear | yes | UQCC3 | assembly of cyt. b | |
| MZM1 | nuclear | no | LYRM7 | assembly of Rieske protein | |
| BCS1 | nuclear | yes | BCS1L | assembly of Rieske protein |