Table 3.
Univariate and Multivariate Cox regression analysis for CRTd responders (a), hospitalization for HF worsening (b), cardiac deaths (c) and all cause of deaths (d)
| Univariate analysis HR (95% CI) | p value | Multivariate analysis HR (95% CI) | p value | |
|---|---|---|---|---|
| A. Multivariate Cox regression analysis for parameters associated with CRT responders | ||||
| Age | 0.102 [0.11–0.968] | 0.048 | 0.713 [0.007–1.773] | 0.276 |
| Automatic | 0.795 [0.567–1.115] | 0.184 | 3.636 [1.271–10.399] | 0.016* |
| Beta blockers | 1.176 [0.806–1.716] | 0.401 | 1.156 [0.745–1.793] | 0.517 |
| BNP | 1.001 [0.989–1.101] | 0.868 | 1.001 [0.889–1.007] | 0.816 |
| COPD | 1.446 [0.948–2.204] | 0.087 | 1.527 [0.935–2.495] | 0.091 |
| CRP | 1.101 [0.992–1.280] | 0.274 | 1.017 [0.995–1.041] | 0.136 |
| HbA1c | 1.118 [0.851–1.315] | 0.643 | 1.181 [0.922–1.472] | 0.123 |
| Hypertension | 0.898 [0.619–1.302] | 0.569 | 0.895 [0.561–1.430] | 0.644 |
| LVEF | 1.006 [0.970–1.044] | 0.736 | 1.036 [0.993–1.081] | 0.102 |
| NYHA 3 | 1.176 [0.840–1.647] | 0.345 | 1.829 [0.923–3.626] | 0.084 |
| Obesity | 1.497 [1.290–1.852] | 0.011 | 1.330 [0.829–1.843] | 0.082 |
| QRS duration | 0.989 [0.971–1.008] | 0.255 | 0.991 [0.971–1.011] | 0.379 |
| SonR | 10.2 [5.227–19.952] | 0.002 | 2.863 [1.537–6.231] | 0.006* |
| 6MWT | 1.001 [0.993–1.007] | 0.926 | 1.010 [0.993–1.007] | 0.994 |
| B. Multivariate Cox regression analysis for parameters associated with hospitalizations for heart failure | ||||
| Age | 1.012 [0.873–1.322] | 0.958 | 0.997 [0.671–1.201] | 0.240 |
| Automatic | 0.795 [0.567–1.115] | 0.184 | 1.166 [0.118–1.504] | 0.895 |
| Beta blockers | 1.301 [0.587–2.885] | 0.517 | 0.844 [0.336–2.122] | 0.718 |
| BNP | 1.002 [1.001–1.301] | 0.011 | 1.002 [1.001–1.040] | 0.125 |
| COPD | 0.561 [0.276–1.141] | 0.111 | 2.364 [0.907–6.158] | 0.078 |
| CRP | 1.011 [0.978–1.046] | 0.507 | 1.032 [0.982–1.084] | 0.219 |
| HbA1c | 1.142 [0.816–1.913] | 0.143 | 0.915 [0.589–1.541] | 0.762 |
| Hypertension | 1.991 [1.003–3.952] | 0.049 | 2.503 [0.809–7.745] | 0.111 |
| LVEF | 1.029 [0.956–1.108] | 0.443 | 1.061 [0.960–1.172] | 0.245 |
| NYHA 3 | 0.531 [0.258–1.096] | 0.087 | 0.962 [0.289–3.202] | 0.950 |
| Obesity | 0.905 [0.276–2.965] | 0.869 | 1.093 [0.220–5.429] | 0.913 |
| QRS duration | 0.964 [0.927–1.020] | 0.066 | 0.960 [0.919–1.003] | 0.069 |
| SonR | 0.074 [0.004–1.292] | 0.074 | 0.679 [0.118–1.154] | 0.932 |
| 6MWT | 0.999 [0.985–1.013] | 0.891 | 0.995 [0.980–1.011] | 0.552 |
| C. Multivariate Cox regression analysis for parameters associated with cardiac deaths | ||||
| Age | 0.953 [0.795–1.541] | 0.543 | 1.362 [0.632–1.872] | 0.361 |
| Automatic | 1.670 [0.489–5.705] | 0.413 | 0.111 [0.001–2.583] | 0.427 |
| Beta blockers | 2.099 [0.525–3.024] | 0.176 | 1.095 [0.048–1.435] | 0.945 |
| BNP | 1.001 [0.998–1.004] | 0.681 | 0.999 [0.996–1.003] | 0.679 |
| COPD | 1.119 [0.031–1.447] | 0.072 | 2.138 [0.942–4.002] | 0.401 |
| CRP | 0.913 [0.807–1.034] | 0.151 | 0.903 [0.734–1.112] | 0.338 |
| HbA1c | 1.601 [0.925–2.563] | 0.142 | 3.224 [0.841–4.389] | 0.106 |
| Hypertension | 0.226 [0.029–1.764] | 0.156 | 0.515 [0.026–1.019] | 0.663 |
| LVEF | 1.127 [0.964–1.316] | 0.133 | 1.126 [0.855–1.482] | 0.397 |
| NYHA 3 | 0.615 [0.180–2.102] | 0.439 | 0.458 [0.008–2.618] | 0.705 |
| Obesity | 2.283 [0.002–3.248] | 0.521 | 0.759 [0.001–1.621] | 0.993 |
| QRS duration | 0.951 [0.885–1.021] | 0.164 | 0.897 [0.782–1.016] | 0.087 |
| SonR | 0.056 [0.001–8.699] | 0.263 | 0.010 [0.001–5.267] | 0.520 |
| 6MWT | 0.992 [0.968–1.016] | 0.509 | 0.973 [0.919–1.031] | 0.355 |
| D. Multivariate Cox regression analysis for parameters associated with all cause deaths | ||||
| Age | 1.782 [1.053–2.302] | 0.001 | 1.362 [0.809–1.780] | 0.563 |
| Automatic | 1.471 [0.570–3.795] | 0.425 | 1.744 [0.270–2.713] | 0.179 |
| Beta blockers | 2.009 [0.582–6.490] | 0.270 | 3.338 [0.684–6.781] | 0.096 |
| BNP | 0.999 [0.996–1.002] | 0.434 | 0.998 [0.994–1.021] | 0.258 |
| COPD | 0.268 [0.106–0.680] | 0.006 | 2.802 [0.493–5.192] | 0.245 |
| CRP | 0.918 [0.837–1.007] | 0.070 | 0.915 [0.792–1.057] | 0.915 |
| HbA1c | 0.832 [0.503–1.742] | 0.430 | 0.587 [0.201–3.105] | 0.224 |
| Hypertension | 0.027 [0.001–1.801] | 0.092 | 0.898 [0.648–1.547] | 0.936 |
| LVEF | 1.008 [0.916–1.110] | 0.869 | 0.879 [0.001–5.644] | 0.713 |
| NYHA 3 | 0.292 [0.096–0.888] | 0.030 | 1.966 [0.030–3.082] | 0.465 |
| Obesity | 2.289 [0.014–3.766] | 0.407 | 0.468 [0.009–1.821] | 0.099 |
| QRS duration | 0.958 [0.907–1.012] | 0.128 | 0.958 [0.885–1.037] | 0.284 |
| SonR | 0.191 [0.005–7.540] | 0.378 | 1.684 [0.101–5.647] | 0.713 |
| 6MWT | 1.009 [0.991–1.028] | 0.339 | 1.004 [0.977–1.031] | 0.791 |
Italic values indicate a significant p value (p < 0.05)
* Is for statistical significant (p < 0.05). BNP, B type natriuretic peptide; COPD, chronic obstructive pulmonary disease; CRP, C reactive protein; HbA1c, glycated hemoglobin 1Ac type; LVEF, left ventricle ejection fraction; NYHA 3, New York Heart Association 3 class; SonR, values of SonR signals; 6MWT, 6 min walking test. Multivariate Cox regression analysis for parameters associated with CRT responders