Table 2. Correlation analysis between YTHDC2 and related genes and markers of immune cells in TIMER.

Description	Gene markers	HNSCC
		None		Purity
		Cor	P	Cor	P
CD8+ T cell	CD8A	0.349	***	0.352	***
	CD8B	0.262	***	0.253	***
T cell (general)	CD3D	0.236	***	0.228	***
	CD3E	0.334	***	0.337	***
	CD2	0.323	***	0.319	***
B cell	CD19	0.285	***	0.287	***
	CD79A	0.309	***	0.314	***
Monocyte	CD86	0.244	***	0.244	***
	CSF1R	0.299	***	0.301	***
TAM	CCL2	0.271	***	0.254	***
	CD68	0.090	0.04	0.086	0.058
	IL10	0.265	***	0.266	***
M1 Macrophage	NOS2	0.337	***	0.331	***
	IRF5	0.258	***	0.263	***
	PTGS2	0.130	*	0.129	*
M2 Macrophage	CD163	0.276	***	0.284	***
	VSIG4	0.196	***	0.196	***
	MS4A4A	0.215	***	0.213	***
Neutrophils	CEACAM8	0.046	0.293	0.045	0.321
	ITGAM	0.319	***	0.317	***
	CCR7	0.320	***	0.314	***
Natural killer cell	KIR2DL1	0.145	**	0.161	**
	KIR2DL3	0.247	***	0.243	***
	KIR2DL4	0.275	***	0.298	***
	KIR3DL1	0.275	***	0.289	***
	KIR3DL2	0.277	***	0.276	***
	KIR3DL3	0.134	*	0.120	*
	KIR2DS4	0.132	*	0.135	*
Dendritic cell	HLA-DPB1	0.238	***	0.236	***
	HLA-DQB1	0.222	***	0.207	***
	HLA-DRA	0.322	***	0.324	***
	HLA-DPA1	0.342	***	0.340	***
	CD1C	0.254	***	0.242	***
	NRP1	0.300	***	0.305	***
	ITGAX	0.293	***	0.308	***
Th1	TBX21	0.300	***	0.300	***
	STAT4	0.290	***	0.285	***
	STAT1	0.350	***	0.354	***
	IFN-γ (IFNG)	0.276	***	0.280	***
	TNF-α (TNF)	0.147	**	0.156	**
Th2	GATA3	0.190	***	0.182	***
	STAT6	0.460	***	0.461	***
	STAT5A	0.320	***	0.315	***
	IL13	0.199	***	0.192	***
Tfh	BCL6	0.363	***	0.369	***
	IL21	0.352	***	0.335	***
Th17	STAT3	0.573	***	0.564	***
	IL17A	0.277	***	0.268	***
Treg	FOXP3	0.422	***	0.431	***
	CCR8	0.519	***	0.521	***
	CD4	0.344	***	0.344	***
	CD25 (IL-2Rα)	0.360	***	0.372	***
	STAT5B	0.408	***	0.407	***
Th9	IRF4	0.392	***	0.399	***
	PU.1 (SPL1)	0.234	***	0.238	***
Th22	IL22	0.167	**	0.155	**
	FOXO4	0.425	***	0.422	***
	AHR	0.329	***	0.329	***
	CD196 (CCR6)	0.401	***	0.404	***
	CD194 (CCR4)	0.498	***	0.496	***

Notes.

^*P < 0.05.

^**P < 0.01.

^***P < 0.001.