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. Author manuscript; available in PMC: 2020 Nov 29.

Published in final edited form as: Adv Anat Pathol. 2020 May;27(3):114–163. doi: 10.1097/PAP.0000000000000256

Image 5. — Broad-Spectrum Epithelial Marker Expression by Sarcoma: (A) I initially misdiagnosed this epitheloid angiosarcoma presenting in the mediastinum as poorly differentiated non-small cell lung carcinoma, (B) based in part, on this keratin AE1/AE3; repeat biopsy demonstrated more obvious vasoformative areas, and I confirmed the diagnosis with ERG (C). (D) This epithelioid malignant neoplasm presenting in the proximal thigh was initially misdiagnosed as metastatic carcinoma based on diffuse, strong EMA-positivity (E); (F) INI1/SMARCB1 loss supports the correct interpretation of epithelioid sarcoma. (G) This undifferentiated malignant neoplasm with osteoclast-like giant cells was initially misdiagnosed a sarcomatoid carcinoma based on this keratin AE1/AE3 (H). (I) Resection demonstrated an abrupt transition from a well-differentiated cartilaginous neoplasm to undifferentiated malignant neoplasm, diagnostic of dedifferentiated chondrosarcoma. (J) Leiomyosarcoma co-expressing keratin AE1/AE1 (K) and SMSA (L).

Image 5. — Broad-Spectrum Epithelial Marker Expression by Sarcoma: (A) I initially misdiagnosed this epitheloid angiosarcoma presenting in the mediastinum as poorly differentiated non-small cell lung carcinoma, (B) based in part, on this keratin AE1/AE3; repeat biopsy demonstrated more obvious vasoformative areas, and I confirmed the diagnosis with ERG (C). (D) This epithelioid malignant neoplasm presenting in the proximal thigh was initially misdiagnosed as metastatic carcinoma based on diffuse, strong EMA-positivity (E); (F) INI1/SMARCB1 loss supports the correct interpretation of epithelioid sarcoma. (G) This undifferentiated malignant neoplasm with osteoclast-like giant cells was initially misdiagnosed a sarcomatoid carcinoma based on this keratin AE1/AE3 (H). (I) Resection demonstrated an abrupt transition from a well-differentiated cartilaginous neoplasm to undifferentiated malignant neoplasm, diagnostic of dedifferentiated chondrosarcoma. (J) Leiomyosarcoma co-expressing keratin AE1/AE1 (K) and SMSA (L).