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Homogeneous vs. Heterogeneous CDX2 Expression: (A) Homogeneous (i.e., diffuse, strong) CDX2 expression is typical of lower GI tumors (i.e., appendiceal mucinous neoplasm and adenocarcinoma and colorectal adenocarcinoma), while (B) heterogeneous (i.e., any staining less than homogeneous) expression is typical of upper GI, pancreatobiliary, and primary mucinous ovarian tumors.
