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. Author manuscript; available in PMC: 2020 Nov 29.

Published in final edited form as: Adv Anat Pathol. 2020 May;27(3):114–163. doi: 10.1097/PAP.0000000000000256

Image 18. — Immunohistochemical Features of Pheochromocytoma/Paraganglioma: (A) This metastatic paraganglioma expresses (B) GATA-3, while (C) SDHB expression is absent (note intact staining in endothelium). (D) In this case, absent tyrosine hydroxylase staining supports a diagnosis of paraganglioma over pheochromocytoma, although 40% of paragangliomas are tyrosine hydroxylase-positive. SDH-deficiency in this case raises the possibility of hereditary paraganglioma-pheochromocytoma.

Image 18. — Immunohistochemical Features of Pheochromocytoma/Paraganglioma: (A) This metastatic paraganglioma expresses (B) GATA-3, while (C) SDHB expression is absent (note intact staining in endothelium). (D) In this case, absent tyrosine hydroxylase staining supports a diagnosis of paraganglioma over pheochromocytoma, although 40% of paragangliomas are tyrosine hydroxylase-positive. SDH-deficiency in this case raises the possibility of hereditary paraganglioma-pheochromocytoma.