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Poorly Differentiated Neuroendocrine Carcinomas Demonstrate Marked Transcription Factor Lineage Infidelity: (A) This small cell carcinoma of endometrial origin was found to express (B) p63, (C) CDX2, (D) c-Myc, (E) SALL4, and (F) PAX8, among others. Note that the PAX8-positvity is no more extensive than positivity for any of the other markers. Poorly differentiated neuroendocrine carcinomas tend to express multiple transcription factors independent of site of origin.
