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Merkel Cell Carcinoma Polyomavirus Large T Antigen Expression in Merkel Cell Carcinoma: CM2B4-positivity in the Merkel cell carcinoma illustrated in Image 20D. Merkel cell carcinoma polyomavirus-positivity is seen in >75% of non-Australian tumors. It tends to correlate with CK20-positivity, which somewhat limits its diagnostic value.
