Fig. 3.

Mean lung concentration–time curves of Emetine in rats and mice after oral administration at a single dose of 1 mg/kg and multi-doses of Q.D. 1 mg/kg in three consecutive days (n = 3). a Distribution of Emetine in the lung of rats post 72 h with 1 mg/kg single oral dose and 1 mg/kg Q.D. for 3 days. b Distribution of Emetine in the lung of mice post 72 h with 1 mg/kg single oral dose and 1 mg/kg Q.D. for 3 days. c Distribution of Emetine in different tissues of mice after intravenous administration of 1 mg/kg in mice