Fig. 4.

Graphic illustration of action Model for Emetine as Anti-SARS-CoV-2 Virus Therapy. Firstly, Emetine could potently inhibit the SARS-CoV-2 virus replication and displayed virus entry blocking effect in Vero cells at low dose. Secondly, Emetine could significantly reduce the LPS induced IL-6 protein level and moderately reduce the TNF-α protein level in the M1 polarized THP-1 macrophages. In addition, in vivo animal PK study revealed that Emetine was enriched in the lung tissue and had a long retention time. In summary, the potent in vitro antiviral replication efficacy, the high enrichment in target tissue combining with the well documented safety profiles in human indicated that low dose of Emetine might be a potentially effective anti-SARS-CoV-2 infection therapy