Table 1.
Major metabolic pathways of commonly used antiretroviral drugs.
| Enzyme | Antiretroviral drug |
|||
|---|---|---|---|---|
| NNRTIs | PIs | CCR5 Coreceptor Inhibitors |
Intergrase Inhibitors | |
| CYP3A4/5 | Nevirapine, Efavirenz, Etravirine, Rilpirine, Emtricitabine | Retonavir, lopinavir, saquinavir, Fosamprenavir, Atazanavir, duranvir | Maraviroc | Elvitegravir Dolutegravir |
| CYP2B6 | Efavirenz, Nevirapine | |||
| CYPC9 | Etravrine, Nevirapine, | |||
| CYPC19 | Etravrine | |||
| CYP2D6 | Nevirapine | Retonavir | ||
| UGT | Etravrine, Rilpivirine, abacavir | Raltegravir, elvitegravir, Dolutegravir | ||