Table C1.
Prevalence of problematic outcomes according to average daily opioid utilisation (oral morphine equivalent (OME) per day) in the POINT cohort (non-imputed data) (95%CI).
| OME (mg) | Wave 1-Baseline | Wave 3-Year 1 | Wave 4-Year 2 | Wave 5-Year 3 | Wave 6-Year 4 | Wave 7-Year 5 | |
|---|---|---|---|---|---|---|---|
| % Indicators of potential extra medical opioid use (ORBIT) | 0 | 17.65 (11.27–25.7) | 2.4 (0.5–6.85) | 6.29 (2.92–11.61) | 3.17 (1.17–6.78) | 5.8 (3.03–9.91) | |
| 1–49 | 30.61 (26.08–35.44) | 34.13 (29.36–39.15) | 26.56 (22.38–31.06) | 26.03 (21.86–30.56) | 21.88 (17.84–26.35) | 15.79 (12.09–20.09) | |
| 50–89 | 35.09 (29.36–41.17) | 43.64 (37.22–50.23) | 35.62 (29.48–42.14) | 36.07 (29.71–42.82) | 27.27 (21.36–33.85) | 25 (18.65–32.25) | |
| 90–199 | 43.14 (37.46–48.97) | 50 (44.28–55.72) | 39.74 (34.23–45.45) | 43.84 (37.9–49.92) | 33.94 (28.38–39.84) | 25.63 (20.6–31.2) | |
| 200+ | 42.01 (34.47–49.83) | 47.34 (39.62–55.15) | 41.62 (34.43–49.08) | 49.03 (40.93–57.18) | 41.72 (33.76–50.02) | 32.28 (24.26–41.15) | |
| % Patient concerns about their opioid use (PODS) | 0 | 17.65 (11.27–25.7) | 4 (1.31–9.09) | 3.5 (1.14–7.97) | 3.7 (1.5–7.48) | 4.83 (2.34–8.7) | |
| 1–49 | 50 (44.94–55.06) | 33.33 (28.6–38.33) | 48.56 (43.68–53.47) | 47.69 (42.77–52.64) | 48.44 (43.34–53.56) | 38.89 (33.69–44.28) | |
| 50–89 | 60 (53.83–65.95) | 48.31 (41.77–54.88) | 62.66 (56.11–68.89) | 65.75 (59.06–72.01) | 63.64 (56.72–70.16) | 54.76 (46.91–62.44) | |
| 90–199 | 66.56 (60.9–71.88) | 54.22 (48.48–59.88) | 73.94 (68.65–78.76) | 69.2 (63.39–74.6) | 68.59 (62.77–74.01) | 58.48 (52.44–64.35) | |
| 200+ | 70.41 (62.92–77.18) | 56.8 (48.98–64.39) | 71.35 (64.26–77.75) | 72.26 (64.5–79.14) | 72.19 (64.32–79.16) | 63.78 (54.78–72.12) | |
| % ICD-10 pharmaceutical opioid dependence (CIDI 3.0) | 0 | 3.2 (0.88–7.99) | 4.9 (1.99–9.83) | 4.23 (1.84–8.17) | 3.38 (1.37–6.84) | ||
| 1–49 | 6.12 (3.96–8.97) | 6.22 (4.1–8.98) | 8.27 (5.8–11.37) | 6.51 (4.26–9.46) | 7.89 (5.27–11.28) | ||
| 50–89 | 7.55 (4.67–11.42) | 6.44 (3.65–10.4) | 11.42 (7.53–16.39) | 7.66 (4.44–12.13) | 9.52 (5.54–15.01) | ||
| 90–199 | 16.39 (12.38–21.08) | 12.38 (8.91–16.59) | 15.22 (11.19–20.01) | 13 (9.27–17.54) | 9.75 (6.52–13.86) | ||
| 200+ | 23.08 (16.95–30.17) | 15.68 (10.76–21.73) | 23.87 (17.4–31.37) | 18.54 (12.69–25.67) | 21.26 (14.5–29.4) |
Note: opioid dependence not collected at Year1.