Table 5.
Correlations between density and visual HRCT indices and lung function parameters
| pO2 (mmHg) | SpO2 (%) | FVC (% pred) | TLC (% pred) | DLCOsb (% pred) | 6MWT distance (m) | sPAP (mmHg) | ||
|---|---|---|---|---|---|---|---|---|
| Volumetric CT | ||||||||
| MLA | −0.139 (0.500) | −0.214 (0.294) | −0.465 (0.019) | −0.337 (0.158) | −0.315 (0.153) | −0.109 (0.699) | 0.039 (0.905) | |
| Skewness | 0.29 (0.180) | 0.294 (0.174) | 0.656 (0.001) | 0.612 (0.009) | 0.581 (0.007) | −0.158 (0.589) | −0.277 (0.410) | |
| Kurtosis | 0.162 (0.483) | 0.145 (0.531) | 0.541 (0.011) | 0.542 (0.037) | 0.549 (0.018) | −0.294 (0.329) | −0.129 (0.705) | |
| % Best score | −0.257 (0.206) | −0.449 (0.021) | −0.368 (0.071) | −0.286 (0.235) | −0.084 (0.709) | −0.186 (0.506) | 0.186 (0.563) | |
| Kazerooni (GG score) | −0.152 (0.458) | −0.27 (0.182) | −0.413 (0.040) | −0.284 (0.238) | 0.014 (0.950) | −0.448 (0.094) | −0.018 (0.956) | |
| Kazerooni (fibrosis score) | −0.147 (0.474) | −0.171 (0.403) | 0.031 (0.881) | 0.102 (0.679) | −0.029 (0.897) | 0.062 (0.825) | 0.034 (0.916) | |
| Incremental CT | ||||||||
| MLA | −0.331 (0.037) | −0.248 (0.123) | −0.616 (<0.001) | −0.366 (0.047) | −0.382 (0.026) | −0.178 (0.407) | 0.087 (0.681) | |
| Skewness | 0.379 (0.023) | 0.272 (0.108) | 0.561 (0.001) | 0.436 (0.018) | 0.583 (0.001) | 0.208 (0.341) | −0.005 (0.984) | |
| Kurtosis | 0.507 (0.001) | 0.431 (0.007) | 0.594 (<0.001) | 0.379 (0.043) | 0.543 (0.001) | 0.08 (0.71) | −0.355 (0.089) | |
| % Best score | −0.359 (0.023) | −0.318 (0.045) | −0.136 (0.415) | −0.149 (0.432) | −0.416 (0.014) | −0.157 (0.464) | 0.176 (0.399) | |
| Kazerooni (GG score) | −0.181 (0.265) | −0.225 (0.162) | −0.058 (0.728) | −0.126 (0.506) | 0.077 (0.667) | −0.319 (0.129) | −0.155 (0.461) | |
| Kazerooni (fibrosis score) | −0.137 (0.4) | −0.144 (0.376) | 0.063 (0.707) | −0.083 (0.663) | −0.481 (0.004) | 0.17 (0.426) | 0.179 (0.391) | |
Data are expressed as Spearman correlation coefficient (p values). Statistically significant results (p < 0.05) are reported in bold
Abbreviations: MLA, mean lung attenuation; GG, ground glass; pO2, O2 arterial partial pressure; SpO2, oxygen saturation; FVC, forced vital capacity; TLC, total lung capacity; DLCOsb, diffusing lung capacity for carbon monoxide single breath; 6MWT, 6-min walking test; sPAP, systolic pulmonary artery pressure