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. 2020 Oct 22;22:1154–1163. doi: 10.1016/j.omtn.2020.10.024

Figure 1.

Figure 1

miR-222 Suppressed the Luciferase Activities of GAS5 and p27, while miR-21 Inhibited the Luciferase Activities of GAS5 and MMP-9

(A) Sequence analysis indicated the potential binding of miR-222 to GAS5. The luciferase activities of wild-type GAS5 were inhibited by miR-222 in HepG2 and LX2 cells. (B) Sequence analysis indicated the potential binding of miR-222 to p27. The luciferase activities of wild-type p27 were inhibited by miR-222 in HepG2 and LX2 cells. (C) Sequence analysis indicated the potential binding of miR-21 to GAS5. The luciferase activities of wild-type GAS5 were inhibited by miR-21 in HepG2 and LX2 cells. (D) Sequence analysis indicated the potential binding of miR-21 to MMP-9. The luciferase activities of wild-type MMP-9 were inhibited by miR-21 in HepG2 and LX2 cells. ∗p < 0.05 versus miR-control.