Table 4.
Spatial distributions of collagen-I and collagen-III as well as co-localization with cells and macrophages
| Parameter (n = 7 PP meshes) | Distance from Fibers | |||||
|---|---|---|---|---|---|---|
| Zone1 000–050 µm | Zone2 050–100 µm | Zone3 100–150 µm | Zone4 150–200 µm | Zone5 200–250 µm | Zone6 250–350 µm | |
| % Col-I+ area | 11.1 (2.1) | 6.7 (1.2) | 6.7 (1.1) | 6.9 (1.3) | 6.5 (1.1) | 6.1 (0.6) |
| % Col-III+ area | 7.5 (0.9) | 8.2 (0.8) | 9.3 (0.9) | 10.2 (1.0) | 10.3 (1.6) | 10.2 (1.8) |
| Col-I+/Col-III+ area ratio | 1.4 (0.2) | 0.9 (0.2) | 0.9 (0.3) | 0.8 (0.3) | 0.8 (0.3) | 0.7 (0.1) |
| % Col-I+ cells | 28.1 (5.8) | 16.7 (4.0) | 14.9 (2.6) | 14.8 (2.3) | 15.9 (1.7) | 17.8 (1.3) |
| % CD68+Col-I+ cells | 19.1 (4.3) | 6.7 (2.3) | 4.2 (1.3) | 2.7 (0.8) | 2.3 (0.8) | 2.3 (0.5) |
| % CD68+Col-I+/CD68+ | 52.2 (8.4) | 46.3 (8.6) | 46.7 (8.8) | 42.3 (9.1) | 40.4 (7.5) | 44.4 (7.2) |
| % Col-III+ cells | 17.7 (2.7) | 15.1 (2.2) | 16.4 (1.9) | 18.6 (1.9) | 20.2 (2.8) | 22.5 (2.5) |
| % CD68+Col-III+ cells | 10.2 (2.3) | 3.0 (0.8) | 2.3 (0.5) | 1.6 (0.2) | 1.2 (0.2) | 1.5 (0.2) |
| % CD68+Col-III+/CD68+ | 29.3 (5.4) | 22.5 (3.2) | 28.4 (2.7) | 30.7 (1.1) | 29.1 (2.2) | 36.5 (2.3) |
Percentage areas of collagen-I and -III (e.g., Col-I+ area) as function of the total area of each regional zone with corresponding collagen ratios. Percentages of cells (e.g., Col-I+ cells) and macrophages (e.g., CD68+Col-I+ cells) co-localizing with collagen-I and -III, and the proportions of co-localizing macrophages relative to the total number of macrophages (e.g., CD68+Col-I+/CD68+) in each regional zone. The data are presented as mean (SE)