TABLE 2.

Recent patents related to recombinant microalgae vaccine in aquaculture.

Number	Patent Number	Pathogen	Antibacterial peptides (AP) Antigen (Ag)	Expression host	Vector	Promoter	Position	Effect	References
1	US2016346373-A1	Beta-nodavirus	Nervous Necrosis Virus (NNV) Capsid protein or fragment thereof	P. tricornutum	pPhaT1	fcpA, fcp B	Vacuole	Improving the effectiveness of oral vaccines	Chen, 2016
2	WO2008027235-A1	WSSV	/	D. salina	pRrMDWK	Constitutive Inducible	Cytoplasm	Improving survival after virus attack	Durvasula and Durvasula, 2008
3	US2011014708-A1	/	LFB VP28	N. oculata	pCB740 pGEM-T	RBCS2, HSP70A	Nucleus Cytoplasm	Improving antibacterial and antiviral activity	Tsai and Li, 2011
4	US2017202940-A1	R. salmoninarum	P57 protein	C. reinhardtii	pUC18 pSSRC7	psbA β2-tubulin	Nucleus Chloroplast	Detecting antibodies in vivo	Sayre et al., 2017
5	US2014170181-A1	WSSV	VP28	Chlorella sp.	pGA4	/	Cytoplasm	100% protection rate	Moi et al., 2014