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. 2020 Nov 25;13:12169–12179. doi: 10.2147/OTT.S283542

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© 2020 Gao et al.

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TAMs-derived exosomes induce the resistance of GC cells to doxorubicin (DOX) in vitro. (A) The AGS cells were co-cultured with TAMs pre-treated with or without 10 µM GW4869 (blocking exosome generation), and then exposed to DOX for 48h. Cell viability and IC50 of DOX was analyzed respectively. (B) The morphology and size distribution of the isolated exosomes were identified using TEM and NTA. (C and D) AGS cells were pre-treated with PBS (ctrl) or TAMs-derived exosomes (TAM Exo) for 24h, then exposed to DOX for 48h. Cell viability, IC50 of DOX and cell apoptosis was detected respectively. **p<0.01, *** p<0.001.