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. 2020 Nov 25;13:12169–12179. doi: 10.2147/OTT.S283542

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© 2020 Gao et al.

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Exosomal transfer of functional miR-223 confers doxorubicin resistance of GC cells. (A) The expression level of miR-223 was detected using RT-qPCR in AGS cells co-cultured with TAMs (with or without GW4869) or TAMs-derived exosomes (TAM Exo). (B) The internalization of exosomes and transfer of Cy3-labeled miR-223 were observed via immunofluorescence. (C and D) The AGS cells were pre-treated with exosomes derived from TAMs which were transfected with miR-223 antagomir (TAM Exo antagomir) or NC control, then exposed to DOX for 48h. Cell viability, IC50 of DOX and cell apoptosis was detected respectively. **p<0.01, *** p<0.001.