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. 2020 Nov 25;13:12169–12179. doi: 10.2147/OTT.S283542

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© 2020 Gao et al.

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Exosomal miR-223 regulates doxorubicin sensitivity through FBXW7 targeting. (A) The expression level of FBXW7 and EMT marker proteins were detected in AGS cells co-cultured with TAMs treated with or without GW4869. (B) The expression level of FBXW7 and EMT marker proteins were detected in AGS cells treated with TAMs-derived exosomes, which were transfected with miR-223 antagomir (TAM Exo antagomir) or NC control. (C) EGFP reporter analysis was performed in GC cells after wild-type or mutant 3ʹUTR reporter plasmids were co-transfected with miR-223 mimic or NC. (D) The expression level of miR-223 was detected using RT-qPCR in GC tissues from DOX-resistant and DOX-sensitive patients. (E) The expression level of FBXW7 was detected using RT-qPCR in GC tissues from DOX-resistant and DOX-sensitive patients. (F) Pearson correlation analysis between miR-223 and FBXW7 expression level was performed in 30 GC patients. NS p>0.05, **p<0.01, *** p<0.001.