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. 2020 Nov 25;15:9447–9467. doi: 10.2147/IJN.S274289

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© 2020 Wang et al.

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Molecular structures and process related to clathrin-mediated endocytosis. (A) Schematic diagram of clathrin molecular (left) and clathrin-coated lattice (right). Reproduced from Smith CJ et al. Clathrin coats at 21 Å resolution: a cellular assembly designed to recycle multiple membrane receptors. EMBO J (1998) 17: 4943–495. Copyright 1998 John Wiley and Sons.²⁷ (B) Clathrin-coated lattice captured by electron microscope (scale bar = 100 nm). Modified with permission of Rockefeller University Press, from Heuser JE, Anderson RGW. Hypertonic media inhibit receptor-mediated endocytosis by blocking clathrin-coated pit formation. Journal of Cell Biology, 1989; 108(2): 389–400, Copyright 1989; permission conveyed through Copyright Clearance Centre Inc.²⁸ (C) Electron microscope graph showing different stages of clathrin-mediated endocytosis of Transferrin modified colloidal gold granules. Modified with permission of Rockefeller University Press, from Harding C, Heuser J, Stahl P. Receptor-mediated endocytosis of transferrin and recycling of the transferrin receptor in rat reticulocytes. Journal of Cell Biology, Aug 1983; 97(2): 329–339, Copyright 1983; permission conveyed through Copyright Clearance Centre Inc.³⁰ (scale bar = 100 nm).