FIGURE 2.

Schematic illustration of the roles of FTO in obesity and tumorigenesis/drug response. (A) As the m⁶A demethylase, FTO post-transcriptionally regulates expression of its critical target genes and thereby contributes to obesity (through affecting adipogenesis and food intake) and cancers (including tumorigenesis, cancer cell growth, migration, and drug response). MA, meclofenamic acid; R-2HG, 2-hydroxyglutarate; EGCG, Epigallocatechin gallate; (B) FTO regulates the development and progression of obesity and cancer through the mTOR or adipofactor-mTOR pathway.