TABLE 1.

Demographic, clinical, and biomarker characteristics of human subjects.

	Normal	MCI	AD	p-value (AD vs. HC/AD vs. MCI)
Number of subjects	5	5	5
Cohort 1
Age [SD]	76.2 [5.97]	76.0 [7.25]	77.6 [3.65]	NS/NS
Sex (F/M)	2/3	2/3	2/3	NS*
MMSE [SD]		29 [2.07]	23 [2.51]	–/0.020
ADAS-70 [SD]		10 [6.19]	19 [6.40]	–/0.047
CDR-Global [SD]		0.50 [0.00]	0.60 [0.22]	–/NS
CDR-Sob [SD]		1.70 [0.27]	3.60 [1.64]	–/0.052
CSF tau (pg/ml) [SD]		75.60 [15.47]	108.80 [49.09]	–/NS
CSF p181-tau (pg/ml) [SD]		36.40 [11.41]	71.00 [35.77]	–/0.075
CSF Aβ 1-42 (pg/ml) [SD]		155.80 [26.60]	128.60 [39.80]	–/NS
Cohort 2
Age [SD]	75.8	66.40 [3.78]	74.60 [8.29]	NS/0.075
Sex (F/M)	3/2	4/1	3/2	NS/0.003*
MMSE [SD]		25.40 [4.88]	18.60 [6.88]	–/ NS
ADAS-70 [SD]		11.40 [6.23]	22.20 [4.44]	–/0.028
CDR-Global [SD]		0.40 [0.22]	1.20 [0.45]	–/0.005
CDR-Sob [SD]		2.10 [1.39]	6.20 [1.82]	–/0.009
CSF tau (pg/ml) [SD]		63.40 [13.59]	105.00 [66.28]	–/NS
CSF p181-tau (pg/ml) [SD]		56.40 [14.54	59.40 [35.21]	–/NS
CSF Aβ 1–42 (pg/ml) [SD]		184.80 [26.57]	178.40 [22.28]	–/NS

Pairwise comparisons between groups were conducted with t-test for continuous variables and Chi-square for categorical variables. NS corresponds to p > 0.1. * Chi-square.