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. 2020 Nov 16;10:571515. doi: 10.3389/fcimb.2020.571515

Table 2.

Detection frequency and copy numbers of nine pathogens from clinical samples.

Pathogens Detection rate; No. of subjects (%) P-valuea Copy numbers; Mean ± SD, Median (IQR) P-valueb
Healthy(n = 144) Chronic periodontitis Healthy(n = 144) Chronic periodontitis
Slight(n = 95) Moderate(n = 245) Severe(n = 208) Slight(n = 95) Moderate(n = 245) Severe(n = 208)
Pg 130 (90.3%) 90 (94.7%) 242 (98.8%) 205 (98.6%) <0.001 3.73 ± 1.43
4.05 (3.07-4.73)
4.75 ± 1.37
5.07 (4.44-5.53)
5.51 ± 0.92
5.70 (5.24-6.02)
5.70 ± 0.90
5.89 (5.44-6.18)
<0.001
Tf 71 (49.3%) 84 (88.4%) 239 (97.6%) 207 (99.5%) <0.001 1.71 ± 1.58
1.89 (0.00-3.11)
3.64 ± 1.46
4.04 (3.20-4.64)
4.45 ± 0.94
4.60 (4.06-5.06)
4.78 ± 0.64
4.86 (4.50-5.18)
<0.001
Td 101 (70.1%) 78 (82.1%) 236 (96.3%) 204 (98.1%) <0.001 2.45 ± 1.39
2.75 (1.24-3.58)
3.47 ± 1.72
3.94 (2.96-4.67)
4.55 ± 1.08
4.73 (4.25-5.20)
4.74 ± 0.91
4.91 (4.43-5.29)
<0.001
Pi 64 (44.4%) 70 (73.7%) 215 (87.8%) 202 (97.1%) <0.001 1.81 ± 2.04
0.00 (0.00-3.95)
3.52 ± 2.15
4.32 (1.38-5.14)
4.51 ± 1.76
5.09 (4.49-5.52)
5.00 ± 1.11
5.21 (4.60-5.67)
<0.001
Fn 144 (100%) 95 (100%) 245 (100%) 208 (100%) NA 5.02 ± 0.61
5.05 (4.59-5.50)
5.30 ± 0.55
5.27 (4.94-5.73)
5.47 ± 0.48
5.53 (5.19-5.80)
5.56 ± 0.45
5.55 (5.33-5.89)
<0.001
Cr 130 (90.3%) 94 (98.9%) 244 (99.6%) 208 (100%) <0.001 3.52 ± 1.15
3.74 (3.06-4.33)
4.36 ± 0.74
4.42 (4.01-4.86)
4.72 ± 0.58
4.78 (4.44-5.11)
4.88 ± 0.51
4.98 (4.58-5.21)
<0.001
Aa 11 (7.6%) 15 (15.8%) 35 (14.3%) 52 (25.0%) <0.001 0.45 ± 0.93
0.0056 (0.00-0.42)
0.59 ± 1.30
0.0041 (0.00-0.04)
0.55 ± 1.28
0.0025 (0.00-0.02)
0.96 ± 1.61
0.0037 (0.00-2.26)
0.107
Pa 137 (95.1%) 89 (93.7%) 232 (94.7%) 206 (99.0%) 0.055 3.94 ± 1.11
4.15 (3.47-4.62)
4.17 ± 1.30
4.39 (3.80-5.03)
4.53 ± 1.28
4.82 (4.28-5.24)
4.92 ± 0.87
5.05 (4.53-5.49)
<0.001
Ec 139 (96.5%) 94 (98.9%) 243 (99.2%) 207 (99.5%) 0.076 3.75 ± 0.85
3.88 (3.20-4.40)
4.23 ± 0.80
4.20 (3.78-4.68)
4.49 ± 0.67
4.59 (4.13-4.93)
4.51 ± 0.65
4.54 (4.08-4.92)
<0.001

aChi-squared test, bKruskal-Wallis One Way Analysis of Variance on Ranks.

NA, not applicable; IQR, interquartile range.