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. 2020 Nov 16;14:588423. doi: 10.3389/fnhum.2020.588423

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Copyright © 2020 Davidson, Lipsman, Meng, Rabin, Giacobbe and Hamani.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ventral tegmental area projection pathway (VTApp) DBS. (A) Outline shows how DBS electrode traverses the VTApp, formerly suggested to be the superolateral branch of the medial forebrain bundle (green). (B) Three-dimensional view from lateral and left. (C) Optimal SCC DBS Fiber Bundle Target Template. Red: Forceps Minor, Blue: Uncinate Fasciculus, Yellow: Cingulate Bundle. Abbreviations: mF10, medial frontal (Brodmann Area 10); Forceps M., forceps minor; Uncinate F., uncinate fasciculus; Cingulum B., cingulum bundle; vSt, ventral Striatum; nAc, nucleus accumbens; Th, thalamus; SCC25, subcallosal cingulate cortex (BA25); Amg, amygdala; ACC, anterior cingulate cortex; MCC, middle cingulate cortex. Adapted and reprinted from Coenen et al. (2018), with permission from Elsevier. Reprinted from Riva-Posse et al. (2014), with permission from Elsevier.