Figure 1.

A Detergent Molecule Binds a Receptor-Induced Pocket in HIV-1 Env

(A) The fusion peptide adopts different conformations in the asymmetric reconstruction of CD4- and 17b-bound B41 SOSIP. Modeled N-terminal residues of each chain are labeled.

(B) Relative location of the binding pocket (left), and greater details of the locations of the DDM-containing and FP-containing pockets (right). The density for DDM in the C3-symmetry map is shown as a side panel for reference.

(C and D) Contact residues (C) and percent conservation of residues (D) lining the DDM pocket.

See also Figures S1 and S7.