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. 2020 Nov 16;11:590660. doi: 10.3389/fgene.2020.590660

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Copyright © 2020 Ma, Lu, Chen, Wu, Jin, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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PPI network complex of DEGs in ovarian aging. Red nodes represent upregulated genes; green nodes represent downregulated genes. Round rectangle nodes represent hub genes (A). Four of the highly connected clusters were identified by centrality calculating algorithms and visualized by the Centiscape plugin of Cytoscape. Interactions are color coded according to combined scores with darker edges corresponding to higher scores (B). Plot of hub genes displayed in top GO terms and KEGG pathways. Size of circles represents the relative mRNA expression of the genes (C).