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. 2020 Nov 16;11:590660. doi: 10.3389/fgene.2020.590660

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Copyright © 2020 Ma, Lu, Chen, Wu, Jin, Zhang and Wang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Experiment validation of hub genes with top high degree scores. Relative mRNA expression levels of hub genes expression in the 24-week-old and 1.5-year-old mice ovary (unpaired Student’s t test) (A). Representative images of IHC detection of selected hub genes (Lcp2, H2-Ab1, Itgb2, and CD14) expression in the 24-week-old and 1.5-year-old mice ovary (B). Relative expression level analysis of LCP2, IGTB2, and CD14 (unpaired Student’s t test) (C). *p < 0.05; **p < 0.005; ***p < 0.001; ****p < 0.0001.