Table 3.

Relationship between alterations in maternal PSS level during different trimesters and infant AD at 6 months.

Alterations of maternal perceived stress level	With AD at 6 months, N (%)	Unadjusted, OR, 95%CI	P-value	Adjustedb, OR, 95%CI	P-value
From the 1st to the 2nd trimester			< 0.001		0.001
Not increased	99 (7.2)	Reference		Reference
Increased	35 (13.7)	2.06 (1.37–3.11)		2.05 (1.33–3.15)
From the 2nd to the 3rd trimester			0.935		0.967
Not increased	118 (8.2)	Reference		Reference
Increased	16 (8.3)	1.02 (0.59–1.77)		0.99 (0.56–1.74)
From the 1st to the 3rd trimester			0.005		0.004
Not increased	103 (7.4)	Reference		Reference
Increased	31 (12.7)	1.82(1.19–2.80)		1.92 (1.22–3.00)

^bAdjusted for maternal age at delivery, ethnicity, education, family income, parity, gestational diabetes mellitus, gestational hypertension, and parental history of allergic diseases.

AD, atopic dermatitis; OR, odds ratio; CI, confidence interval; PSS, perceived stress scale. Bold values mean P < 0.05.