Table 3.
Acetic acid induced Writhing test for Z. armatum fruit (ZAF) bark (ZAB) extracts, and crude alkaloids (ZAFA and (ZABA).
| Treatment | Dose (mg/kg) | No of Writhing in 10 min | % inhibition of writhing |
|---|---|---|---|
| Saline | 10 mL/kg | 40.67 ± 0.55 | 0% |
| Diclofenac | 10 | 21.83 ± 0.40 | 46.33∗∗∗ |
| ZAF | 100 | 31.83 ± 0.60 | 21.74 |
| ZAF | 200 | 25.17 ± 0.30 | 38.12 |
| ZAF | 300 | 24 ± 4.81 | 40.99∗ |
| ZAFA | 50 | 24 ± 0.21 | 40.98∗ |
| ZAFA | 100 | 22 ± 0.25 | 45.91∗∗∗ |
| ZAB | 100 | 30.33 ± 0.61 | 18.95 |
| ZAB | 200 | 27 ± 0.44 | 33.62 |
| ZAB | 300 | 25.83 ± 0.30 | 36.49∗ |
| ZABA | 50 | 28 ± 0.30 | 31.16 |
| ZABA | 100 | 25 ± 0.40 | 38.53∗∗ |
Comparison of different doses with standard drug (Diclofenac) in acetic induced writhing mice. Data represented as mean ± SEM values of six animals. The data was analyzed by ANOVA followed by Dunnett's test using Graph pad prism software which indicate that data are statistically significant at <0.05∗, <0.01∗∗ and <0.001∗∗∗ as compare with control.