Fig. 4.

Rupture is not associated with larger infarcts or thinner infarct walls. Comparison of morphometric end points between mice dying of rupture (R) and animals dying in the absence of rupture (no rupture, NR) showed no significant differences between groups. Infarct size (A), infarct volume (B), volume of noninfarcted myocardium (C), maximal, minimal, and mean thickness of the infarcted wall (D, E, F, respectively), maximal, minimal, and mean wall thickness of the noninfarcted myocardial segments (G, H, I, respectively), and infarct length (J) were comparable between groups (P = not significant, n = 6–7/group). Time points studied histologically were comparable between groups, as there was no significant difference in time of death (R group: 5.0 ± 0.53 days, n = 7; R group: 5.16 ± 0.4, n = 6).