Table 3.
Rupture-related mortality in wild-type mice undergoing nonreperfused myocardial infarction protocols
| Strain | Sex | Age, wk | Mortality, % | Duration of Follow-up | Rupture rates, rupture × 100/total deaths | Rupture Assessment Criteria | Ref. |
|---|---|---|---|---|---|---|---|
| C57BL/6J | M+F | 18 | 45 | 7 | 33 | Hem or RS | (43) |
| C57BL/6 | M | 8–10 | 35.6 | 28 | 78.7 | Autopsy (not otherwise specified) | (46) |
| C57BL/6J | M+F | 10–12 | 35 | 28 | 100 | Hem and RS | (14) |
| C57BL/6 | M | 12 | 46.6 | 56 | 92 | Hem and RS | (87) |
| C57BL/6 | M | 8–12 | 22.7 | 7 | 80 | Hem and RS | (93) |
| C57BL/6J | M+F | 12 | 42 | 28 | 63 (M), 38.5 (F) | Hem and RS | (48) |
| C57BL/6 | M | 8–10 | 52 | 7 | 60.6 | Hem | (45) |
| C57BI/6J | M+F | N/A | 45 | 14 | 100 | Autopsy (not otherwise specified) | (15) |
| C57BL/6 | M | 8–16 | 75 | 28 | 100 | Autopsy (not otherwise specified) | (2) |
| N/A | M+F | N/A | 12 | 7 | 100 | Autopsy (not otherwise specified) | (26) |
| C57Bl/6J | M+F | N/A | 40 | 7 | 100 | Autopsy (not otherwise specified) | (75) |
| C57BL/6 | M | 10 | 55 | 28 | 96 | Hem and/or RS | (96) |
| C57BL/6J | M | 8–12 | 40 | 28 | 100 | Autopsy (not otherwise specified) | (77) |
| C57BL/6 | M | 8–12 | 41 | 56 | 80 | RS | (7) |
| C57BL/6 | M | 8–12 | 20 | 14 | 83 | Autopsy (not otherwise specified) | (12) |
| C57BL/6 | M | 12–20 | 65 | 14 | 26.1 | Autopsy (not otherwise specified) | (84) |
| C57BL/6/129/svj | M | 8–12 | 34.6 | 42 | 11.5 | RS | (50) |
| C57BL/6 | M | 8–12 | 39.3 | 28 | 57.7 | Histology | (64) |
| C57BL/6 | M | 10–12 | 35 | 28 | 85 | Autopsy (not otherwise specified) | (53) |
| C57BL/6J | M+F | 8–12 | 16 | 28 | 73 | Hem or RS | (85) |
| C57BL/6 | M | 12 | 58 | 28 | 92 | Autopsy (not otherwise specified) | (81) |
| C57BL/6 | M | 10–12 | 48 | 28 | 62.5 | Hem and RS | (58) |
| C57BL/6 | M+F | N/A | 44 | 28 | 63.6 | Histology | (46) |
| C57BL/6J | M | 16 | 60 | 28 | 100 | Autopsy (not otherwise specified) | (39) |
| C57BL/6 × FVB | F | 12–14 | 15 | 7 | 100 | Hem and/or RS | (83) |
| C57BL/6 | M | 10–16 | 51 | 28 | 70 | Hem or RS | (97) |
| C57BL/6 | M | 10 | 50 | 7 | 100 | Autopsy (not otherwise specified) | (92) |
| C57BL/6 | M | 9–12 | 50 | 28 | 87.4 | Hem and RS | (82) |
| C57BL/6 | M+F | 7–8 | 60 | 120 | 100 | Autopsy (not otherwise specified) | (70) |
| C57BL/6 | M | 8–10 | 22 | 14 | 100 | Hem and RS | (71) |
| C57Bl/6 | M | 8–10 | 53 | 7 | 55.8 | Histology | (59) |
| C57BL/6 | M | 8 | 31 | 5 | 33.6 | RS | (54) |
| C57BL/6 | M | 8–10 | 41 | 28 | 69.7 | Hem and RS | (44) |
| C57BL/6 | M | 9–12 | 27.1 | 7 | 100 | Hem | (63) |
| C57BL/6 | M+F | N/A | 40 | 28 | 85.5 | Hem | (34) |
| C57BL/6 | M | 10–12 | 19.8 | 28 | 100 | Autopsy (not otherwise specified) | (3) |
| C57BL/6 | M+F | 12–16 | 6 | 14 | 50 | RS and Histology | (88) |
| C57BL/6J | M | 11–12 | 28 | 10 | 75 | Hem and Infusion | (67) |
| FVB | M+F | N/A | 43.2 | 20 | 55 | Hem | (86) |
| C57BL/6 | M | N/A | 66 | 7 | 40 | Autopsy (not otherwise specified) | (61) |
| C57BL/6 | M | 8–28 | 25 | 30 | 33.6 | Infusion | (32) |
| C57BL/6 | M | 10–12 | 40 | 28 | 80 | Hem | (49) |
| FVB/njcl | F | 8–12 | 35 | 28 | 88 | Hem | (37) |
| C57BL/6J | M | 10–18 | 15% | 14 | 60 | Histology | (78) |
| C57BL/6 | M | N/A | 40 | 10 | 100 | Autopsy (not otherwise specified) | (69), |
| C57BL/6J | M | 8 | 46 | 7 | 68 | Autopsy (not otherwise specified) | (79) |
| C57BL/6J | M | 12–13 | 54 | 28 | 38.5 | Histology | (65) |
| C57BL/6 | M | 12–16 | 23.5 | 7 | 100 | Autopsy (not otherwise specified) | (42) |
| C57BL/6 | M | 8–12 | N/A | N/A | 30 | RS | (36) |
| BalbC | M | 10–12 | 6 | 28 | 33.3 | Hem | (89) |
| C57BL/6 | M | 10–12 | 19 | 28 | 81.8 | Hem | (89) |
| FVB | M | 10–12 | 37 | 28 | 45.8 | Hem | (89) |
| 129S6 | M | 10–12 | 42.8 | 28 | 93.3 | Hem | (89) |
| Swiss | M | 10–12 | 14.5 | 28 | 75 | Hem | (89) |
| FVB/N | M+F | 12–16 | 16.5 (M), 15.7 (F) | 7 | 7.8 (M), 0 (F) | Hem and RS | (27) |
| C57BL/6 | M+F | 12–16 | 25.5 (M), 11.2 (F) | 7 | 56 (M), 45.5 (F) | Hem and RS | (27) |
| 129sv | M+F | 12–16 | 45.6 (M), 11.3 (F) | 7 | 93.4 (M), 72.8 (F) | Hem and RS | (27) |
M, male; F, female; N/A, not available; Hem, hemothorax (clot or blood in chest); RS, rupture site in gross pathology.