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JQ1 arrested cell cycle but not induced apoptosis. A, B, KYSE450 cells were treated with the indicated JQ1 for 24 hours, and the cell cycle distribution was analysed using flow cytometry. C, D, Administration of JQ1 down‐regulated CCND1 expression. ****P ≤ .001. E, F, Apoptosis assay of KYSE450 cells after incubation with vehicle or JQ1 for 72 hours. The data were means ± SD. G, Activation of caspase‐3 and cleavage of PARP treated with indicated JQ1 for 72 hours in KYSE450 cells
