Figure 2.

DSC ameliorates DSS‐mediated loss of intestinal barrier integrity and inflammatory response. Colitis was induced as described in Materials and Methods and treated with or without DSC (50 mg/kg). A, The mRNA expression of claudin‐1, ZO‐2 and Muc‐2 (Mucin‐2) in the colon. B, Representative bands and quantitative analyses of claudin‐1 and ZO‐2 were measured in the colon. C, The mRNA levels of cytokines in colonic tissues. D, Representative bands and quantitative analysis of COX‐2 and iNOS in colonic tissues, β‐actin was used as loading control. E, Serum cytokines. F, colonic MPO activities. Data shown are means ± SEM of n = 8 in each group. *P < 0.05 vs Control (CTL), ^#P < 0.05 vs DSS‐treated mice