FIGURE 1.

Polydatin alleviates insulin resistance and liver fibrosis in fructose‐fed rats. (A) A schematic representation of the experiments performed and timeline with rats. (B) Serum concentration of insulin was measured. Blood glucose profiles in oral glucose tolerance test (C) and insulin tolerance test (D) were measured, respectively. (E) Representative microphotographs of Masson‐stained and Sirius red‐stained paraffin‐embedded sections of liver tissues were shown (200× magnification: bars, 100 μm; 400× magnification: bars, 50 μm). Fibrotic areas of the Sirius red‐stained liver sections were quantitatively compared. Each value is shown as mean ± SEM (n = 6‐8 in panel A, B and C; n = 3‐4 in panel D). ^# P < .05, ^## P < .01, ^### P < .001 compared with the normal control; *P < .05, **P < .01, ***P < .001 compared with the fructose control