FIGURE 2.

LINC00346 knockdown suppressed glioma cell proliferation, migration, invasion and tumour growth in vitro and in vivo. A, Cell proliferation was examined using the CCK‐8 assay in U87 and U251 cells after LINC00346 knockdown. B, The percentage of apoptotic cells was determined by flow cytometry with an annexin V‐FITC antibody and propidium iodide staining. C, Effects of LINC00346 knockdown on the migration and invasiveness of U87 and U251 cells. D, Xenograft tumours from nude mice. E, The expression levels of LINC00346 in tumour tissue samples from two groups were measured by qRT‐PCR. F, Tumour growth curves were constructed by measuring tumour volume every 5 d for 30 d after glioma cell injection. G, The weight of tumours excised from the mice in each treatment group was determined on day 30 after injection (n = 4, each group). ^* P < .05