FIGURE 1.

MLL‐AF9‐induced AML in Tgif1^−/− mice was more aggressive with a shorter survival time than that in Tgif1^+/+ mice. Lin^‐ bone marrow cells (Lin^‐HSPCs) from Tgif1^+/+ or Tgif1^−/− mice were transduced with MLL‐AF9‐GFP retrovirus and transduced cells transplanted into sub‐lethally irradiated Tgif1^+/+ and Tgif1^−/− recipient mice, respectively. Six weeks after transplant, the percentages of A, GFP⁺ cells; B, myeloid cells (CD11b⁺ and Gr‐1⁺) and C, B‐lymphocytes (B220⁺) in peripheral blood (PB) were analysed by flow cytometry. D, Kaplan‐Meier survival curves for indicated mice in MLL‐AF9‐induced AML