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. 2020 Nov 27;12(11):965–975. doi: 10.4254/wjh.v12.i11.965

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©The Author(s) 2020. Published by Baishideng Publishing Group Inc. All rights reserved.

This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial.

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Restorative effects of obeticholic acid on proteasomal and lysosomal activities in acetaldehyde-generating system-human immunodeficiency virus-exposed Huh7.5-CYP cells. A: Chymotrypsin-like activity, proteasome; B: Trypsin-like activity, proteasome; C: Cathepsin B activity, lysosome; D: Cathepsin L activity, lysosome. All data were obtained from 3 independent experiments and presented as mean ± SEM. Bars with different letters are significantly different at P ≤ 0.05. AGS: Acetaldehyde-generating system; HIV: Human immunodeficiency virus; OCA: Obeticholic acid.