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. Author manuscript; available in PMC: 2020 Nov 30.
Published in final edited form as: J Med Chem. 2019 Jul 3;62(14):6814–6823. doi: 10.1021/acs.jmedchem.9b00825

Figure 2.

Figure 2.

Chemical structures of compounds used in this study. (A) Natural (1 – 3) and synthetic (5 – 9) butyrophilin ligands bind to BTN3A1 and promote Vγ9Vδ2 T cell activation. Zoledronate (4) promotes indirect activation through the build-up of 2 and/or 3. POM = pivaloyloxymethyl, CH2OC(O)C(CH3)3. (B) Synthesis of C-HMHP (10) and POM2-C-HMHP (11).