. Author manuscript; available in PMC: 2021 Jun 19.

Published in final edited form as: ACS Chem Biol. 2020 Jun 3;15(6):1408–1416. doi: 10.1021/acschembio.9b01050

Table-3.

Summary of activity data for human amylin and consensus sequences, showing pEC₅₀ (pEC₅₀ = −log₁₀ (EC₅₀) and E_max values at hAMY_1(a) receptors. Separate controls with different samples of human amylin were run for each consensus sequence.

	pEC₅₀	Fold Change	E_max	n
Human amylin	8.91 ± 0.07	−4	100	4
Primate consensus	8.33 ± 0.13^*	−4	123 ± 14.2	4
Human amylin	8.94 ± 0.06	−3	100	5
Mammalian consensus	8.50 ± 0.12^*	−3	99.1 ± 13.3	5
Human amylin	8.90 ± 0.06	−4	100	5
Vertebrate consensus	8.33 ± 0.14^*	−4	102 ± 6.58	5

p < 0.05 by unpaired Student t-test compared to human amylin.