Table 3.
Adverse events entire cohort (N=93)
| Grade 1/2 AEs | Grade 3/4 AEs | |||
|---|---|---|---|---|
| Atrial fibrillation (20) Atelectasis (18) Pneumothorax (17) Effusion (16) Pain (5) Pneumonia (4) Chylothorax (3) Hypotension (3) Hypocalcemia (3) Rash (2) Constipation (2) Anemia (2) ACS, arterial injury, atrial flutter, confusion, diarrhea, esophagitis, hypoglycemia, ileus, narcotic OD (1) |
Pneumonitis (5) Pneumonia (4) Respiratory failure (3) RLN injury (3) Dyspnea (3) Pulmonary edema (3) Atelectasis (2) Pulmonary embolus (2) AKI, anemia, aspiration, bronchial obstruction, chylothorax, DTs, effusion, empyema, esophagitis, hemorrhage, hypocalcemia, hyponatremia, hypotension, hypoxia, lymphopenia, necrotic muscle flap, sepsis, ventricular arrhythmia, UTI, wound infection (1) |
|||
| Grade 5 AEs | ||||
| Demographic | Resection | EGFR AB | Gr 5AE | POD |
| 43 M | R pneumonectomy | No | PPE | 6 |
| 52 M | Bilobectomy | Yes | Hemorrhage | 23 |
| 61 M | Lobectomy | Yes | BPF | 28 |
| 63 F | L pneumonectomy | Yes | Aspiration | 29 |
| 71 F | Lobectomy | Yes | Pneumonitis | 45 |
AE, adverse event; CT, cardiothoracic; ACS, acute coronary syndrome, OD, overdose; AKI, acute kidney injury; DTs, delirium tremors; UTI, urinary tract infection; M male: F, female: EGFR AB, panitumab; R, right; L, left; PPE, post-pneumonectomy pulmonary edema; BPF, broncho-pleural fistula; POD, post-opertative day. Events were reported by each institution per the NCI common terminology criteria for adverse events (CTCAE) v3 in 0229 and v4 in 0839.