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Flowchart of trial screening, eligibility, and inclusion. Disease-related outcomes (DROs) includes outcomes related to disease control and/or survival; non-DRO endpoints include those assessing disease- or treatment-related toxicities, supportive measures, and similar. Abbreviations: RCT, randomized controlled trials; DRO, disease-related outcome; PEP, primary endpoint; PFS, progression-free survival; OS, overall survival.
